PD-1 Introduction Investigate the anti-tumor effects of PD-1 antibodies in your mouse cancer model research. Our monoclonal Anti-PD-1 antibodies effectively target the Programmed Cell Death Protein 1 (PD-1) receptor, which normally suppresses T-cell activity on tumor cells. Blocking PD-1 reinvigorates anti-tumor immunity, a key mechanism in immunotherapy development. Anti-mouse PD-1 Antibody Clones Leinco Technologies offers three (3) unique anti-PD-1 monoclonal antibodies: 29F.1A12 (in vivo GOLD Version), RMP1-14, 384-35 (fully murinized). All three of our PD-1 antibodies are perfectly suited for in vivo blocking of PD-1 signaling in mouse models. They also boast extensive, multi-year publication records that consistently support this application. Clone 384-35 is part of a new class of mouse anti-mouse antibodies that significantly increases survival past 100 days compared to RMP1-14 and shows tumor volume more than 2.5 fold smaller compared to RMP1-14. The available clones all have extensive publication records to support them. Leinco’s anti-mouse PD-1 antibodies are available in both in vivo GOLD™ and in vivo PLATINUM™  formats. When selecting a PD-1 antibody for your mouse in vivo studies, you have excellent options, each with distinct advantages. Clone RMP1-14: The Gold Standard for In Vivo Blocking The RMP1-14 clone stands out with the most extensive publication record specifically for in vivo blocking of PD-1 signaling. If your research solely focuses on in vivo PD-1/PD-L pathway inhibition, RMP1-14 is a highly validated and reliable choice. Clone 29F.1A12: Versatile PD-1 Antibodies for Comprehensive Research For researchers needing broader applications, our 29F.1A12 clone offer remarkable versatility. Both have strong publication records for in vivo PD-1 blocking, similar to RMP1-14. However, their utility extends far beyond. This PD-1 antibody is also suitable for: In vitro PD-1 neutralization Western blotting Immunohistochemistry Immunofluorescence Flow cytometry This multi-application capability is a significant advantage if you plan to run in vitro or diagnostic experiments alongside your in vivo studies, streamlining your workflow and maximizing your research potential. Which PD-1 Clone Is Best For My Research? At Leinco Technologies, all of our PD-1 antibodies are meticulously developed and quality tested to bind to PD-1 and meet the lower endotoxin levels and highest purity levels for mouse in vivo experiments. However, depending on your specific mouse model and research requirements, one PD-1 antibody clone may be better suited for your needs. While each of the PD-1 antibodies available in our catalog were developed by different researchers at various times, they were all consistently produced using established hybridoma technology, ensuring reliable and high-quality reagents for your studies.